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Bloodthistle seems to act as a normal drug which makes the user feel great and increase spellpower(according to WoW anyway).I guess this is why the blood elves seem to favour it over anything else.Bloodthistle is frowned upon by the blood elves and distribution of it is probaly illegal so dealers have to get around...although there appear to be bongs in the Inns in Silvermoon...maybe other drugs are allowed?
Other drugs in-game that I know of are alcohol and tobacco.I imagine tobacco is allowed and quite frequent among the people among Azeroth (atleast to the alliance) as there was a shop in Stratholme and various snuff boxes found around the world.There is also an item given out from a questgiver in Blasted Lands called R.O.I.D.S which increases strength much like steroids but I doubt they are widespread as they are created using items found of animals in the Blasted Lands.
I seem to recall a quest in STV in which you go around gathering snuff for some guy.
Probably this quest
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